Registro completo |
Provedor de dados: |
OAK
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País: |
Japan
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Título: |
Mycophenolic acid and its derivatives as potential chemotherapeutic agents targeting inosine monophosphate dehydrogenase in Trypanosoma congolense
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Autores: |
Suganuma, Keisuke
Sarwono, Albertus Eka Yudistira
Mitsuhashi, Shinya
Jąkalski, Marcin
Okada, Tadashi
Nthatisi, Molefe
Yamagishi, Junya
Ubukata, Makoto
Inoue, Noboru
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Data: |
2016-07
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Ano: |
2016
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Resumo: |
This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense. The proliferation of T. congolense was completely inhibited by adding <1 mu M MPA and its derivatives. In addition, the IMP dehydrogenase in T. congolense was molecularly characterized as the target of these compounds. The results suggest that MPA and its derivatives have the potential to be new candidates as novel trypanocidal drugs.
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Idioma: |
Inglês
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Identificador: |
http://ir.obihiro.ac.jp/dspace/handle/10322/4492
info:doi/10.1128/AAC.02816-15
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Editor: |
American Society for Microbiology
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